SAT Question 3a715eca: Transitions answer and explanation

English - Transitions - Cause Effect Transition
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In retrospect, one of the lessons of the 2003 Human Genome Project is that a gene is affected by many factors, not the least of which is its interactions with the protein products of other genes. ______ rather than just focusing on the human genome, efforts to better understand gene mutations related to disease have begun to consider the human proteome, the complete set of proteins expressed by human genes.
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Difficulty:Hard
Which choice completes the text with the most logical transition?