Explanation
Correct answer: A.
Choice A is the best answer. "With this in mind" logically signals that the activity described in this sentence—Dominguez’s use of techniques like decalcomania to produce unpredictable abstract patterns—is a result of his desire to include random elements in his art.
Why the other choices are wrong
Choice B
Choice B is incorrect. "On the contrary" illogically signals that the activity in this sentence opposes or is contrary to Dominguez’s desire to use random elements in his art. Instead, his use of decalcomania is a result of that desire.
Choice C
Choice C is incorrect. "In conclusion" illogically signals that the activity in this sentence is a conclusion or summary of Dominguez’s desire to use random elements in his art. Instead, his use of decalcomania is a result of that desire.
Choice D
Choice D is incorrect. "Regardless" illogically signals that the activity in this sentence occurs despite Dominguez’s desire to use random elements in his art. Instead, his use of decalcomania is a result of that desire.