SAT Question 083a35dc: Boundaries answer and explanation

English - Boundaries - Comma And Coordinating Conjunction Between Clauses
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Po’Pay was a Tewa leader from Ohkay Owingeh, a pueblo located about twenty-five miles north of present-day Santa Fe, New Mexico. He was instrumental in organizing the Pueblo Revolt of ______ as a result of his leadership, the Spanish colonizers were expelled from the region for a time.
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Difficulty:Medium
Which choice completes the text so that it conforms to the conventions of Standard English?