SAT Question b6560e5a: Boundaries answer and explanation

English - Boundaries - Comma And Coordinating Conjunction Between Clauses
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Materials scientist Marie-Agathe Charpagne and her colleagues believed they could improve on the multicomponent alloy NiCoCr, an equal-proportions mixture of nickel (Ni), cobalt (Co), and chromium (Cr), by replacing chromium with ruthenium ______ the alloy that resulted, NiCoRu, turned out to be an unsuitable replacement for NiCoCr.
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Difficulty:Medium
Which choice completes the text so that it conforms to the conventions of Standard English?